Flavonoids and Steroids of Dracocephalum komarovii
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The perennial herbaceous plant Dracocephalum komarovii Lipsky  (Lamiaceae) grows in Central Asia on rocky slopes in the upper mountain zone at elevations of 2,300–3,600 m above sea level. Plants of the genus Dracocephalum are used in folk medicine to treat colds, headaches, angina, hypotension, tracheitis, atherosclerosis, heart diseases, bronchitis, neuralgia, migraine, and toothache [2, 3, 4, 5, 6]. Previous studies of the chemical components of D. komarovii isolated diterpenoids that exhibited activity against Trypanosoma cruzi, a vector of Chagas’ disease and American trypanosomiasis in Central and South America [7, 8, 9, 10].
The aerial part of D. komarovii (2 kg) gathered in Tashkent Oblast (Uzbekistan) during flowering was extracted with EtOH (70%) at room temperature. The condensed extract was chromatographed over a column of silica gel using a hexane–EtOAc gradient (16:1, 12:1, 9:1, 4:1, 2:1) to produce pure 1 (10 mg), 2(11 mg), and seven fractions (1–7). Each fraction...
The work was supported financially by the Program of Key International Science and Technology Cooperative Projects (No. 2016YFE0120600) and the Central Asian Drug Discovery and Development Center of the Chinese Academy of Sciences.
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