Diterpenoid Alkaloids from Aconitum brachypodum
Three new C-19 diterpene alkaloids, along with two known ones, were isolated from the roots of Aconitum brachypodum Diels. The structures of the new alkaloids were established as N-deethyl-3-Oacetylchasmaconitine (1), N-deethyl-3-O-acetylyunaconitine (2), and N-deethyl-3-O-acetyljesaconitine (3). Their structures were elucidated by extensive spectroscopic methods, including 1D (1H, 13C) NMR and 2D NMR (1H–1H COSY, TOCSY, ROESY, HSQC, and HMBC) experiments, as well as high-resolution electrospray ionization mass spectrometry (HR-ESI-MS).
KeywordsC-19 diterpenoid alkaloid Aconitum brachypodum
The authors are grateful to the Analytical Center of the Chemistry College of Henan University for measuring NMR, MS, and IR data.
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