Chemistry of Natural Compounds

, Volume 54, Issue 1, pp 131–136 | Cite as

Synthesis and Anti-Inflammatory Effect of Sinomenine 4-Hydroxy Esters

  • Dan Wang
  • Rong Zhang
  • Chunbao Jiang
  • Aun Raza
  • Jian Tang
  • Zhen Ouyang
  • Zhaoliang Su
  • Huaxi Xu
Article
  • 2 Downloads

In order to find more active anti-neuroinflammatory sinomenine derivatives, 17 sinomenine 4-hydroxy esters were designed and prepared. All synthesized derivatives were structurally confirmed by ESI-MS and PMR. Their anti-neuroinflammatory effects were evaluated using LPS-stimulated BV-2 microglia cells. Among them, four compounds presented more than 80% of cell viability. Compound 8 showed remarkable inhibition of nitric oxide (NO) release by the Griess method. Furthermore, esters 5–9 were tested to check their suppressive effects on xylene-induced ear edema. It was observed that 8 was more active and less toxic than 5–7 with shorter aliphatic chains.

Notes

Acknowledgment

This work was partly supported by National Natural Science Foundation of China (81373480, 81573529, 21372056), Zhenjiang Social Development Project (SH2014062), and Jiangsu University Graduate Innovation Fund (Y13A096).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Dan Wang
    • 1
    • 3
  • Rong Zhang
    • 1
  • Chunbao Jiang
    • 1
  • Aun Raza
    • 1
  • Jian Tang
    • 1
  • Zhen Ouyang
    • 1
    • 3
  • Zhaoliang Su
    • 2
  • Huaxi Xu
    • 2
  1. 1.School of PharmacyJiangsu UniversityZhenjiangP. R. China
  2. 2.School of MedicineJiangsu UniversityZhenjiangP. R. China
  3. 3.School of Food and Biological EngineeringJiangsu UniversityZhenjiangP. R. China

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