Synthesis and Antibacterial Activity of Calycanthaceous Alkaloid Derivatives
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A series of 45 calycanthaceous alkaloid derivatives with the tetrahydropyrroloindole core structure was synthesized from tryptophan in good yields. The synthesized compounds were evaluated against five strains of bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coil, Ralstonia solanacearum, and Pseudomonas aeruginosa). The bioassays indicated that among the synthesized compounds, compounds b3 and b4 exhibited a high degree of activity towards Gram positive B. subtilis. Compounds a14 and a18 displayed a high degree of activity towards R. solanacearum. These results will pave the way for further design, structural modification, and development of calycanthaceous alkaloids as antibacterial agents.
Keywordscalycanthaceous alkaloids synthesis antibacterial activity agrochemicals tryptophan
This work was supported by the National Natural Science Foundation of China (31360079, 21372185, and 21502073), the Natural Key Research and Development Program of China (No. 2017YFD0200506), the Natural Science Foundation of Jiangsu Province (Grants No. BK 20150465), and the Marine Equipment and Technology Institute of Jiangsu University of Scince and Technology.
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