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Chemistry of Natural Compounds

, Volume 54, Issue 1, pp 127–130 | Cite as

Synthesis and Antibacterial Activity of Calycanthaceous Alkaloid Derivatives

  • Shaojun Zheng
  • Yongdong Gu
  • Rui Zhu
  • Longbo Li
  • Hongjin Bai
  • Jiwen Zhang
Article

A series of 45 calycanthaceous alkaloid derivatives with the tetrahydropyrroloindole core structure was synthesized from tryptophan in good yields. The synthesized compounds were evaluated against five strains of bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coil, Ralstonia solanacearum, and Pseudomonas aeruginosa). The bioassays indicated that among the synthesized compounds, compounds b3 and b4 exhibited a high degree of activity towards Gram positive B. subtilis. Compounds a14 and a18 displayed a high degree of activity towards R. solanacearum. These results will pave the way for further design, structural modification, and development of calycanthaceous alkaloids as antibacterial agents.

Keywords

calycanthaceous alkaloids synthesis antibacterial activity agrochemicals tryptophan 

Notes

Acknowledgment

This work was supported by the National Natural Science Foundation of China (31360079, 21372185, and 21502073), the Natural Key Research and Development Program of China (No. 2017YFD0200506), the Natural Science Foundation of Jiangsu Province (Grants No. BK 20150465), and the Marine Equipment and Technology Institute of Jiangsu University of Scince and Technology.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Environmental and Chemical EngineeringJiangsu University of Science and TechnologyZhenjiangP. R. China
  2. 2.Key Laboratory of Protection & Utilization of Biological Resources in Tarim Basin of Xinjiang Production and Construction Corps/College of Life SciencesTarim UniversityAlar XinjiangP. R. China
  3. 3.Key Laboratory of Botanical Pesticide R & D in Shaanxi ProvinceYanglingP. R. China

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