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Chemistry of Natural Compounds

, Volume 54, Issue 1, pp 106–111 | Cite as

Synthesis and Cytotoxicity Evaluation of Pentacyclic Triterpene–Phenol Nitrogen Mustard Conjugates

  • Jia-yan Huang
  • Lin-dong Yang
  • Chun-hua Su
  • Xiang-wu Chu
  • Jiang-yu Zhang
  • Sheng-ping Deng
  • Ke-guang Cheng
Article
  • 46 Downloads

Using a reported pharmacophore, 4-[N,N-bis(2-chloroethyl)-amino]phenol, and pentacyclic triterpenes, pharmacologically and structurally diverse components of natural products, six pentacyclic triterpene-4-[N,N-bis(2-chloroethyl)-amino]phenol conjugates were synthesized by click chemistry. Their cytotoxicities against the BEL-7404 and NCI-H460 tumor cell lines were evaluated by the MTT assay. The in vitro results from the cytotoxicity assay indicated that at a compound concentration of 20 μM, these conjugates showed low toxicity (< 16%) toward the tested tumor cells in culture.

Keywords

pentacyclic triterpenes nitrogen mustards 4-[N,N-bis(2-chloroethyl)-amino]phenol cytotoxicity 

Notes

Acknowledgment

This study was financially supported by grants from the National Natural Science Foundation of PRC (21562006), Guangxi Natural Science Foundation of China (2015GXNSFAA139186), Guangxi_s Medicine Talented Persons Small Highland Foundation (1506), Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University), and Ministry of Education of China (CMEMR2013-A01, CMEMR2013-C02).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Jia-yan Huang
    • 1
  • Lin-dong Yang
    • 2
  • Chun-hua Su
    • 1
  • Xiang-wu Chu
    • 1
  • Jiang-yu Zhang
    • 1
  • Sheng-ping Deng
    • 1
  • Ke-guang Cheng
    • 1
  1. 1.School of Chemistry and Pharmacy of Guangxi Normal University, State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal ResourcesGuilinP. R. China
  2. 2.Department of Obstetrics and Gynecology, Nanjing Jinling HospitalNanjingP. R. China

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