Two new sesquiterpenoid derivatives, attributable to the eudesmane type (1, named septemlobin E) and the vetispirane type (2, named septemlobin F), were isolated from the whole plant of Solanum septemlobum. Their structures were elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS and 1D and 2D NMR (1H–1H COSY, HMQC, HMBC, and ROESY). In vitro, the two sesquiterpenoid derivatives were found to show significant cytotoxicity against three cancer cell lines (P-388, HONE-1, and HT-29), and gave IC50 values in the range 3.0–7.1 μM.
Solanum septemlobumseptemlobins E and F cytotoxic activity
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This study was financially supported by the Natural Science Foundation of China (21372189). The authors are grateful to Wen-Yan Wang and Li Shen (School of Pharmaceutical Science, Yantai University) for the measurements of FAB-MS, HR-FAB-MS, UV, IR, and NMR spectra. The authors also gratefully acknowledge Hong-Bo Wang (School of Pharmaceutical Science, Yantai University) for the bioactivity screenings.