A New 2-(2-Phenylethyl)Chromone From Aquilaria sinensis

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A new 2-(2-phenylethyl)chromone, 5-hydroxy-8-methoxy-2-[2-(4′methoxyphenyl)-ethyl]chromone (1), was isolated from Aquilaria sinensis (Lour.) Spreng., together with six other known compounds. Their structures were elucidated by analysis of spectroscopic data. The antibacterial activities of these compounds were determined, with compounds 6 and 7 showing significant antibacterial activities against Staphylococcus aureus, and compound 1 exhibiting the best activity against MRSA out of all the isolated compounds. Structure activity relationship analysis revealed that it is crucial for antibacterial activity that the A-ring is substituted.

Keywords

Aquilaria sinensis 2-(2-phenylethyl)chromone derivatives antibacterial activity 

Notes

Acknowledgment

We thank the Foundation (81102418, 31100496, 81203006) of the National Natural Science Foundation of China. The work was also supported by the Scientific Research Innovation Team Foundation of the Logistics University of CPAPF (WHTD201304). We thank Alison McGonagle, PhD, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Z. D. Lei
    • 1
    • 2
  • D. L. Liu
    • 1
  • Y. M. Zhao
    • 1
  • X. X. Gao
    • 2
  1. 1.Tianjin Key Laboratory for Prevention and Control of Occupational and Environmental Hazard, Logistics College of Chinese People’s Armed Police ForcesTianjinP. R. China
  2. 2.Department of Traditional Chinese MedicineGuangdong Pharmaceutical CollegeGuangdongP. R. China

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