A New Ferulic Acid Derivative and Other Anticoagulant Compounds from Angelica sinensis
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A new ferulic acid derivative, (1S)-2-O-Z-feruloyl-1-(4-hydroxyphenyl)ethane-1,2-diol (1), together with five known compounds 2–6, was isolated from the radix of Angelica sinensis. Their structures were elucidated on the basis of spectroscopic data and comparison with literature data. Compounds 1–6 were evaluated for their anticoagulant activities in vitro. The results have shown that all the compounds prolong thrombin time, but had no significant effects in modulating prothrombin time.
KeywordsAngelica sinensis ferulic acid derivative anticoagulation activity
The authors acknowledge the technical assistance of Ji-Xia Zhang (School of Pharmacy, Xinxiang Medical University, P. R. China) for determining ESI-MS and NMR spectra. This work was financially supported by the National Natural Science Foundation of China (Grant Nos. 81202916 and 31400305), the Project for Youth Backbone Teachers in University of Henan Province (Grant Nos. 2013GGJS-129 and 2015GGJS-130), the Science and Technology Project of Henan Province (Grant No. 152102310113), the Science and Technology Project of the Education Department of Henan Province (Grant No. 14A360012), and the High Educated Talents Fund of Xinxiang Medical University.
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