A New Sydonic Acid Derivative From a Marine Derived-Fungus Aspergillus sydowii
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Methyl (3-hydroxy-4-(2-hydroxy-6-methylheptan-2-yl)benzoyl)glycinate (1), a new sydonic acid derivative with glycinate, together with sydonic acid (2), sydowic acid (3), and 7-deoxy-7,14-didehydrosydonic acid (4), were isolated from a marine-derived Aspergillus sydowii strain CUGB-F126. Their structures were elucidated by spectroscopic analysis, including high-resolution mass spectroscopy, and 1D and 2D NMR techniques. All of these compounds did not show inhibitory activity against Staphylococcus aureus and Candida albicans.
Keywordsmarine-derived fungus Aspergillus sydowii sydonic acid glycinate
This work was supported by the Fundamental Research Funds for the Central Universities (2-9-2015-165) and key lab of marine bioactive substance and modern analytical technique, SOA (MBSMAT-2016-04).