The reaction of paeoniflorin (PF) with refluxing MeOH in the presence of cation exchanger KU-2-8 (H+) formed a mixture of the 4-O-methyl- and 4-oxo-9-O-methyl ethers (1:1, overall yield 90%) that were separated by chromatography over silica gel. The reaction of PF with EtOH and BuOH under analogous conditions also formed mixtures of the ethyl and butyl ethers from which 4-oxo-9-O-ethyl(butyl) ethers were isolated as the tetra-O-acetates. The structures of the obtained compounds were confirmed using PMR and 13C NMR spectra.
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The work was supported financially by the RFBR (Grant 15-03-03101a).
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2017, pp. 754–757.
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Baltina, L.A., Shabieva, E.R., Kondratenko, R.M. et al. Reaction of Paeoniflorin with Lower Alcohols in the Presence of Cation Exchanger. Chem Nat Compd 53, 887–890 (2017). https://doi.org/10.1007/s10600-017-2148-3
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DOI: https://doi.org/10.1007/s10600-017-2148-3