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Two New 2-Arylbenzofurans from the Stems of Nicotiana tabacum and Their Bioactivities

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Chemistry of Natural Compounds Aims and scope

Two new 2-arylbenzofurans, 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-7-ol (1) and 2-(4-methoxyphenyl)-3,5-dimethylbenzofuran-6-ol (2), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-TMV and cytotoxicity activities. The results showed that compounds 1 and 2 exhibited high anti-TMV activities with inhibition rates of 29.2% and 30.8% at the concentration of 20 μM. These rates are close to that of positive control (31.1%). Compounds 1 and 2 also showed moderate to weak cytotoxicities against the tested human tumor cell lines with IC50 values in the range of 2.2–8.2 μM.

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Acknowledgment

This research was supported by the National Natural Science Foundation of China (Nos. 21562049, 31360081, and 31400303), the Applied Fundamental Foundation of Yunnan Province (Nos. 2014FB163, 2015FB162), and the Research Foundation of China Tobacco Company (No. 110201502006).

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Authors and Affiliations

  1. School of Pharmaceutical Science & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, 650500, Kunming, P. R. China

    Xingmeng Xu, Jianlian Shi, Wenfei Chen, Liang Deng & Yadong Guo

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd, 650231, Kunming, P. R. China

    Xingmeng Xu, Jianlian Shi, Chao Li, Wei Zhang, Xiaofeng Shen, Xiaowei Ma & Xue-Mei Li

Authors
  1. Xingmeng Xu
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  2. Jianlian Shi
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  3. Chao Li
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  4. Wei Zhang
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  5. Xiaofeng Shen
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  6. Xiaowei Ma
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  7. Wenfei Chen
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  8. Liang Deng
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  9. Xue-Mei Li
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  10. Yadong Guo
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Corresponding authors

Correspondence to Xue-Mei Li or Yadong Guo.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2017, pp. 751–753.

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Xu, X., Shi, J., Li, C. et al. Two New 2-Arylbenzofurans from the Stems of Nicotiana tabacum and Their Bioactivities. Chem Nat Compd 53, 883–886 (2017). https://doi.org/10.1007/s10600-017-2147-4

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  • DOI: https://doi.org/10.1007/s10600-017-2147-4

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