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Synthesis and Hydroxyl Radical Scavenging Activity of 4-Aryl-3,4-Dihydrocoumarins

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Chemistry of Natural Compounds Aims and scope

Twelve 4-aryl-3,4-dihydrocoumarins were synthesized by the condensation of phenols with the corresponding substituted cinnamic acids in the presence of nitrobenzene and sulfated montmorillonite K-10. This method displayed the property of green chemistry with respect of reuse of the catalyst. These compounds were evaluated for hydroxyl radical scavenging activity in vitro. Results showed that compounds with 7,8-dihydroxy groups had relatively strong hydroxyl radical scavenging activity.

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Acknowledgment

This work was financially supported by the Project of Shandong Province Higher Educational Science and Technology Program (J14M02), the Science and Technology Research Program of Shandong Academy of Medical Sciences (2014-4), and Shandong Provincial Natural Science Foundation (ZR2015YL041).

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Authors and Affiliations

  1. Institute of Materia Medica, Shandong Academy of Medical Sciences, 250062, Jinan, P. R. China

    Na Li, Bing Wang, Jing-yong Sun, Xiao-jing Wang & Jie Sun

  2. School of Medicine and Life Sciences, University of Jinan and Shandong Academy of Medical Sciences, Jinan, 250062, P. R. China

    Na Li, Bing Wang, Jing-yong Sun, Xiao-jing Wang & Jie Sun

  3. Key Lab. of Rare and Uncommon Diseases of Shandong Province, 250062, Jinan, P. R. China

    Na Li, Bing Wang, Jing-yong Sun, Xiao-jing Wang & Jie Sun

Authors
  1. Na Li
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  2. Bing Wang
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  3. Jing-yong Sun
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  4. Xiao-jing Wang
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  5. Jie Sun
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Corresponding authors

Correspondence to Xiao-jing Wang or Jie Sun.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2017, pp. 733–736.

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Li, N., Wang, B., Sun, Jy. et al. Synthesis and Hydroxyl Radical Scavenging Activity of 4-Aryl-3,4-Dihydrocoumarins. Chem Nat Compd 53, 860–865 (2017). https://doi.org/10.1007/s10600-017-2141-x

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  • DOI: https://doi.org/10.1007/s10600-017-2141-x

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