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A New Chalcone and Antioxidant Constituents of Glycyrrhiza glabra

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A new chalcone, glycyglabrone (1), has been isolated from the roots of Glycyrrhiza glabra, together with three known compounds, licoagrochalcone B (2), licochalcone C (3), and kanzonol Y (4). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Glycyglabrone (1) and licochalcone C (3) exhibited potent free radical scavenging activity, with IC0.200 values of 4.6 ± 0.6 and 8.2 ± 0.9 μM, respectively, in the diphenylpicrylhydrazyl radical (DPPH) decoloration assay.

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This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.

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Correspondence to Jih-Jung Chen.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2017, pp. 538–540.

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Chen, JJ., Cheng, MJ., Shu, CW. et al. A New Chalcone and Antioxidant Constituents of Glycyrrhiza glabra . Chem Nat Compd 53, 632–634 (2017).

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