New betulonic acid conjugates were synthesized in high yields by reacting 2-perfluoroacyl-3-chloro-2-cycloalken-1-ones, which were prepared by treating F-containing cyclic β-triketones with oxalylchloride, with equivalent amounts of betulonic acid amides of aminoalkyl hydrochlorides in the presence of Et3N in CHCl3 .
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The work was supported financially by the National Academy of Sciences of Belarus and the Siberian Branch, Russian Academy of Sciences (Grant X15CO-001).
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2017, pp. 412–416.
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Khlebnikova, T.S., Piven′, Y.A. & Lakhvich, F.A. Synthesis of New Betulonic Acid Conjugates with 2-Perfluoroacylcycloalkane-1,3-Diones Using Polymethylenediamine Linkers. Chem Nat Compd 53, 486–491 (2017). https://doi.org/10.1007/s10600-017-2028-x
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DOI: https://doi.org/10.1007/s10600-017-2028-x