Cytotoxic Constituents of the Twigs of Homalium stenophyllum
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The family Flacourtiaceae consists of ca. 1000 species distributed between 93–100 genera. Homalium is one of the largest genera with 200 species. There is scant chemical information on the family and still less for the genus. In fact, less than 10 species of this genus have been reported in the chemical literature . Homalium stenophyllum Merr. et Chun is an understorey tree about 40 m high and widely distributed in the rainforest of the temperate and subtropical regions . H. stenophyllum is a unique local medicinal plant with its roots and leaves used as traditional folk medicine in Hainan . The chemical constituents of the genus consist of alkaloids, glycosides, triterpenes, coumarin, etc. [4, 5, 6, 7, 8]. These constituents showed various biological activities, such as antivirus, antidiabetes, and other pharmacological activities [9, 10]. In the course of our previous investigation on bioactive chemical constituents from the crude extracts of medicinal plants growing in...
KeywordsEtOAc Daidzein Isocoumarin Syringaresinol Cancer Cell Line HeLa
This work was supported by the National Natural Science Foundation of China (Nos. 21362009, 81360478, and 81160391), the International S&T Cooperation Program of China (ISTCP) (No. 2014DFA40850), and the National Natural Science Foundation of Hainan Province (No. 20152038). The authors thank Prof. Qiong-Xin Zhong, College of Life Science, Hainan Normal University, for the collection and identification of the plant material.
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