Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 362–364 | Cite as

Cytotoxic Constituents of the Twigs of Homalium stenophyllum

  • Zhong-Qi Zhang
  • Cai-Juan Zheng
  • Meng Bai
  • Xiao-Bao Li
  • Xiao-Ping SongEmail author
  • Chang-Ri HanEmail author

The family Flacourtiaceae consists of ca. 1000 species distributed between 93–100 genera. Homalium is one of the largest genera with 200 species. There is scant chemical information on the family and still less for the genus. In fact, less than 10 species of this genus have been reported in the chemical literature [1]. Homalium stenophyllum Merr. et Chun is an understorey tree about 40 m high and widely distributed in the rainforest of the temperate and subtropical regions [2]. H. stenophyllum is a unique local medicinal plant with its roots and leaves used as traditional folk medicine in Hainan [3]. The chemical constituents of the genus consist of alkaloids, glycosides, triterpenes, coumarin, etc. [4, 5, 6, 7, 8]. These constituents showed various biological activities, such as antivirus, antidiabetes, and other pharmacological activities [9, 10]. In the course of our previous investigation on bioactive chemical constituents from the crude extracts of medicinal plants growing in...


EtOAc Daidzein Isocoumarin Syringaresinol Cancer Cell Line HeLa 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the National Natural Science Foundation of China (Nos. 21362009, 81360478, and 81160391), the International S&T Cooperation Program of China (ISTCP) (No. 2014DFA40850), and the National Natural Science Foundation of Hainan Province (No. 20152038). The authors thank Prof. Qiong-Xin Zhong, College of Life Science, Hainan Normal University, for the collection and identification of the plant material.


  1. 1.
    O. A. Ekabo, N. R. Farnsworth, and T. Santisuk, Phytochemistry, 32, 747 (1993).CrossRefGoogle Scholar
  2. 2.
    A. Mosaddik, I. Paul, P. Forster, and P. G. Waterman, Nat. Prod. Res., 21, 1191 (2007).CrossRefPubMedGoogle Scholar
  3. 3.
    J. P. Tian, Y. Y. Hu, J. Q. Zhang, and M. S. Liu, J. Hainan Med. Coll., 14, 122 (2008).Google Scholar
  4. 4.
    X. Y. Chai, Y. N. Lu, H. Y. Ren, and P. F. Tu, Chin. J. Chin. Mater. Med., 31, 269 (2006).Google Scholar
  5. 5.
    H. Manfred and E. Corinne, Helv. Chim. Acta, 86, 233 (2003).CrossRefGoogle Scholar
  6. 6.
    J. A. Lamberton and S. R. Johns, Aust. J. Chem., 22, 1315 (1969).CrossRefGoogle Scholar
  7. 7.
    E. A. Opinya, F. R. Norman, S. Thawatchai, and V. Reutrakul, Phytochemistry, 32, 747 (1993).CrossRefGoogle Scholar
  8. 8.
    P. G. Waterman and K. Shaari, Phytochemistry, 39, 1415 (1995).CrossRefGoogle Scholar
  9. 9.
    J. E. Okokon, B. S. Antia, and B. N. Ita, J. Med. Plant Res., 1, 134 (2007).CrossRefGoogle Scholar
  10. 10.
    P. Y. Chung, L. Y. Chung, Y. F. Ngeow, S. H. Goh, and Z. Imiyabir, Pharm. Biol., 42, 292 (2004).CrossRefGoogle Scholar
  11. 11.
    J. Wang, Y. Zhang, Y. Yuan, and G. Y. Chen, J. Hainan Nor. Uni., 24, 1621 (2011).Google Scholar
  12. 12.
    J. Ma, S. H. Jones, R. Marshall, X. H. Wu, and S. M. Hech, Bioorg. Med. Chem. Lett., 15, 813 (2005).CrossRefPubMedGoogle Scholar
  13. 13.
    W. W. Tang, H. H. Xu, D. Q. Zeng, and L. J. Yu, Fitoterapia, 83, 513 (2012).CrossRefPubMedGoogle Scholar
  14. 14.
    Y. X. Cheng, J. Zhou, and N. H. Tan, Acta Bot. Yunnanica, 23, 352 (2001).Google Scholar
  15. 15.
    P. Chen and J. S. Yang, Chin. Pharm. J., 43, 1669 (2008).Google Scholar
  16. 16.
    S. Q. Yuan, N. J. Yu, Y. M. Zhao, and B. Xu, J. Chin. Med. Mater., 31, 1172 (2008).Google Scholar
  17. 17.
    H. L. Wei, S. X. Zhou, Y. Jiang, Y. L. Song, J. Li, and P. F. Tu, Chin. J. Chin. Mater. Med., 38, 1197 (2013).Google Scholar
  18. 18.
    S. A. Shahzad, C. Venin, and T. Wirth, Eur. J. Org. Chem., 12, 3465 (2010).CrossRefGoogle Scholar
  19. 19.
    X. He and R. H. Liu, J. Argic. Food Chem., 54, 7069 (2006).CrossRefGoogle Scholar
  20. 20.
    Y. Q. Chen, J. Su, Y. T. Shen, H. H. Chen, L. Y. Kong, and W. D. Zhang, Chin. Trad. Herb. Drugs, 40, 516 (2009).Google Scholar
  21. 21.
    Z. X. Zhang, H. H. Xu, D. M. Cheng, Y. L. Wu, and J. F. Fan, J. South Chin. Agric. Univ., 21, 29 (2000).Google Scholar
  22. 22.
    T. Mosmann, J. Immunol. Methods, 65, 56 (1983).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of EducationHainan Normal UniversityHaikouP. R. China

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