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Synthesis and Antioxidant Properties of 5,6,7,8-Tetrahydroxyflavone

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Chemistry of Natural Compounds Aims and scope

Flavones are a group of plant secondary metabolites with multiple biological properties. In the present study, 5,6,7,8-tetrahydroxyflavone (5,6,7,8-THF) was synthesized and characterized. In vitro antioxidant study, the effect of 5,6,7,8-THF on total antioxidant activity, reducing power, DPPH radical scavenging, ABTS radical scavenging, superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide radical scavenging, and ferrous chelating activities was examined. According to the results, 5,6,7,8-THF showed excellent free radical scavenging effect and reducing power but weak the ferrous chelating activity. In conclusion, 5,6,7,8-THF can be regarded as an excellent source of antioxidants.

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Acknowledgment

Financial support from the National Natural Science Foundation of China (81202458), China Postdoctoral Science Foundation (2012M521926), and Scientific Research Foundation of Gansu Province (1308RJYA061) is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Pharmacy, Lanzhou General Hospital, Lanzhou Command of CPLA, 730050, Lanzhou, P. R. China

    Linlin Jing, Huiping Ma, Pengcheng Fan & Zhengping Jia

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  1. Linlin Jing
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  2. Huiping Ma
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  3. Pengcheng Fan
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  4. Zhengping Jia
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Corresponding author

Correspondence to Zhengping Jia.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2017, pp. 213–217.

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Jing, L., Ma, H., Fan, P. et al. Synthesis and Antioxidant Properties of 5,6,7,8-Tetrahydroxyflavone. Chem Nat Compd 53, 248–253 (2017). https://doi.org/10.1007/s10600-017-1963-x

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  • DOI: https://doi.org/10.1007/s10600-017-1963-x

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