Chemistry of Natural Compounds

, Volume 53, Issue 2, pp 248–253 | Cite as

Synthesis and Antioxidant Properties of 5,6,7,8-Tetrahydroxyflavone

  • Linlin Jing
  • Huiping Ma
  • Pengcheng Fan
  • Zhengping JiaEmail author

Flavones are a group of plant secondary metabolites with multiple biological properties. In the present study, 5,6,7,8-tetrahydroxyflavone (5,6,7,8-THF) was synthesized and characterized. In vitro antioxidant study, the effect of 5,6,7,8-THF on total antioxidant activity, reducing power, DPPH radical scavenging, ABTS radical scavenging, superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide radical scavenging, and ferrous chelating activities was examined. According to the results, 5,6,7,8-THF showed excellent free radical scavenging effect and reducing power but weak the ferrous chelating activity. In conclusion, 5,6,7,8-THF can be regarded as an excellent source of antioxidants.


flavonoid 5,6,7,8-tetrahydroxyflavone synthesis antioxidant activity chrysin 



Financial support from the National Natural Science Foundation of China (81202458), China Postdoctoral Science Foundation (2012M521926), and Scientific Research Foundation of Gansu Province (1308RJYA061) is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Linlin Jing
    • 1
  • Huiping Ma
    • 1
  • Pengcheng Fan
    • 1
  • Zhengping Jia
    • 1
    Email author
  1. 1.Department of Pharmacy, Lanzhou General HospitalLanzhou Command of CPLALanzhouP. R. China

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