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Synthesis and Characterization of Fullero-C60 α-Amino Acids with Antiviral Properties

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Chemistry of Natural Compounds Aims and scope

New functionalized fullero-C60 amino acids were synthesized as the free acids and sodium salts N-C60(H)6[Gly-ONa]6∙10H2O (1), N,N-C60(H)8[L-Lys-ONa]4∙10H2O (2), composite N,N-C60 *(H)5[(Gly*-ONa)3(L-Lys-ONa)2] ∙10H2O (3), and composite N,N-C60 *(H)7[(Gly*-ONa)3(L-Asp*-ONa)2-L-Arg-ONa] ∙10H2O (4). Their antiviral activities against virus A/H5N1 were studied in vitro in PEKC cell culture. It was shown that the synthesized compounds as the sodium salts were capable of suppressing replication of A/H5N1 bird-flu virus. Compound 4 had the greatest antiviral activity.

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Notes

  1. Studies conducted at D. I. Ivanovsky Institute of Virology, Ministry of Health of Russia, Moscow.

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Authors and Affiliations

  1. Research Institute, Department of Organic Chemistry, National University, 17 Prosp. Rudaki, Dushanbe, 734025, Tajikistan

    Sh. Kh. Khalikov, D. Sharipova, S. Z. Zafarov, M. Umarkhon & S. V. Alieva

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  1. Sh. Kh. Khalikov
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  2. D. Sharipova
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  3. S. Z. Zafarov
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  4. M. Umarkhon
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  5. S. V. Alieva
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Correspondence to Sh. Kh. Khalikov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 102–108.

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Khalikov, S.K., Sharipova, D., Zafarov, S.Z. et al. Synthesis and Characterization of Fullero-C60 α-Amino Acids with Antiviral Properties. Chem Nat Compd 53, 121–127 (2017). https://doi.org/10.1007/s10600-017-1924-4

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  • DOI: https://doi.org/10.1007/s10600-017-1924-4

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