Five acylation derivatives (1a–1e) were prepared by acylation of cytochalasin B (1), which was isolated from the marine-derived fungus Curvularia lunata. Compound 1 and its acylation derivatives 1a–1e were evaluated for their antiviral and cytotoxic activities in vitro. In particular, compound 1e exhibited potent antiviral activity against HSV and EV71 with IC50 values of 29.5 and 21.4 μM, respectively, which were 4-fold and 11-fold stronger than that of the positive control, ribavirin.
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Acknowledgment
This work was supported by Marine Special Public Welfare Scientific Research, State Oceanic Administration of China (No. 201405038), Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, and the Taishan Scholars Program, China.
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 93–95.
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Zhang, XQ., Guan, FF., Li, DB. et al. Preparation, Structure Elucidation, and Antiviral and Cytotoxic Activities of Acylation Derivatives of Cytochalasin B. Chem Nat Compd 53, 109–113 (2017). https://doi.org/10.1007/s10600-017-1921-7
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DOI: https://doi.org/10.1007/s10600-017-1921-7