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Synthesis of New Sesquiterpenoid Thio-Derivatives Based on Betulenone

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Chemistry of Natural Compounds Aims and scope

Caryophylla-4,8-dien-5-one (betulenone) was synthesized from α-betulenol in 96% yield. Thioacetates and sulfides with aromatic and heterocyclic fragments were newly synthesized from it in yields up to 95% and diastereomeric excesses (de) up to 80% via addition of thioacetic acid and thiols.

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Acknowledgment

The work was supported financially by the RFBR (Project No. 16-03-01064) using equipment at the Khimiya Center for Collective Use (CCU), Inst. Chem., Komi SC, UB, RAS.

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Authors and Affiliations

  1. Institute of Chemistry, Komi Scientific Center, Ural Branch, Russian Academy of Sciences, 48 Pervomaiskaya, Syktyvkar, 167982, Russia

    Yu. V. Gyrdymova, D. V. Sudarikov, S. A. Rubtsova & A. V. Kuchin

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  1. Yu. V. Gyrdymova
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  2. D. V. Sudarikov
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  3. S. A. Rubtsova
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  4. A. V. Kuchin
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Correspondence to Yu. V. Gyrdymova.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 56–60.

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Gyrdymova, Y.V., Sudarikov, D.V., Rubtsova, S.A. et al. Synthesis of New Sesquiterpenoid Thio-Derivatives Based on Betulenone. Chem Nat Compd 53, 66–71 (2017). https://doi.org/10.1007/s10600-017-1913-7

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  • DOI: https://doi.org/10.1007/s10600-017-1913-7

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