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A New Benzenoid and Anti-Inflammatory Constituent of Capparis acutifolia

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Chemistry of Natural Compounds Aims and scope

A new benzenoid, propyl 7-methoxybenzo[d][1,3]dioxole-5-carboxylate (1), has been isolated from the stems of Capparis acutifolia, together with five known compounds, rutin (2), 3β-hydroxystigmast-5-en-7-one (3), 6β-hydroxystigmast-4-en-3-one (4), sitosterol trans-ferulate (5), and sitosterol cis-ferulate (6). The structure of the new compound 1 was determined through spectroscopic and MS analyses. Rutin (2) exhibited potent inhibition, with IC50 value of 1.26 ± 0.15 μg/mL, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2 ·–) generation.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.

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Authors and Affiliations

  1. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Jih-Jung Chen & Tai-Chi Wang

  2. Department of Medical Research, China Medical University Hospital, 404, Taichung, Taiwan

    Jih-Jung Chen

  3. Chung-Jen Junior College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  4. Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 333, Taoyuan, Taiwan

    Hsiang-Ruei Liao

  5. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, 404, Taichung, Taiwan

    Yueh-Hsiung Kuo

  6. School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, 807, Taichung, Taiwan

    Ih-Sheng Chen

  7. Department of Medical Education and Research, Kaohsiung Veterans General Hospital, 813, Kaohsiung, Taiwan

    Chih-Wen Shu

  8. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  9. School of Pharmacy, College of Pharmacy, China Medical University, 404, Taichung, Taiwan

    Yun-Ping Lim

  10. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  11. Department of Pharmacy, Quanzhou Medical College, 362000, Quanzhou, P. R. China

    Rong Xu

Authors
  1. Jih-Jung Chen
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  2. Wen-Lung Kuo
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  3. Hsiang-Ruei Liao
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  4. Yueh-Hsiung Kuo
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  5. Ih-Sheng Chen
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  6. Chih-Wen Shu
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  7. Ping-Jyun Sung
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  8. Yun-Ping Lim
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  9. Tai-Chi Wang
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  10. Ming-Jen Cheng
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  11. Rong Xu
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2017, pp. 21–23.

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Chen, JJ., Kuo, WL., Liao, HR. et al. A New Benzenoid and Anti-Inflammatory Constituent of Capparis acutifolia . Chem Nat Compd 53, 21–23 (2017). https://doi.org/10.1007/s10600-017-1901-y

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  • DOI: https://doi.org/10.1007/s10600-017-1901-y

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