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A New Monoterpenoid Indole Alkaloid from Tabernaemontana corymbosa

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Chemistry of Natural Compounds Aims and scope

Tabernaemontana corymbosa is used in folk medicine for the treatment of hypertension, sore throat, and abdominal pain by the Dais in Yunnan Province. The crude alkaloid extract of T. corymbosa were successively subjected to D-101 macroporous resin, MCI gel, and ODS column chromatography and purified via preparative HPLC to afford a new aspidospermar-type monoterpenoid indole alkaloid, named tabercarpamine K (1). The structure of 1 was elucidated using spectroscopic methods. Compared to the structure of vincamine, a hydroxyl group is substituted at C-19 and a proton, instead of a hydroxyl, is attached to C-16 in 1.

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Acknowledgment

The work was supported by the National Science Foundation of China (21476217).

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Authors and Affiliations

  1. School of Food and Biological Engineering, Zhengzhou University of Light Industry, Henan Provincial Collaborative Innovation Center for Food Production and Safety, Dongfeng Road, 450002, Zhengzhou, P. R. China

    Xue Peng Yang, Ke Ma, Xian Mei Hu, Jian Bin Ye & Yin Liu

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  1. Xue Peng Yang
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  2. Ke Ma
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  3. Xian Mei Hu
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  4. Jian Bin Ye
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  5. Yin Liu
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Corresponding author

Correspondence to Ke Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2016, pp. 237–238.

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Yang, X.P., Ma, K., Hu, X.M. et al. A New Monoterpenoid Indole Alkaloid from Tabernaemontana corymbosa . Chem Nat Compd 52, 269–271 (2016). https://doi.org/10.1007/s10600-016-1611-x

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  • DOI: https://doi.org/10.1007/s10600-016-1611-x

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