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Chemistry of Natural Compounds

, Volume 51, Issue 5, pp 1003–1005 | Cite as

Activity of Thermopsis schischkinii Alkaloids Against Influenza A(H1N1)pdm09 Virus

  • I. P. TsypyshevaEmail author
  • E. G. Galkin
  • I. P. Baikova
  • N. I. Fedorov
  • P. R. Petrova
  • Ya. R. Orshanskaya
  • V. A. Fedorova
  • V. V. Zarubaev
Article

Influenza is an acute viral infection that can easily become a pandemic because of the rate of spread and characteristic high percentage of lethal outcomes [1]. As a rule, chemotherapy agents play a decisive role in such epidemic situations so that the development of effective anti-influenza agents with new mechanisms of antiviral activity remains crucial and has become a worldwide trend for drug discovery in general [2, 3]. Agents of plant origin, including quinolizidine alkaloids, are being extensively examined [4, 5, 6, 7].

The goals of the present work were to screen the anti-influenza activity of alkaloids from Thermopsis schischkinii (Fabaceae), which is broadly distributed in the Republic of Bashkortostan (RB), to isolate total alkaloids from the plant, to separate them into fractions, and to identify the pure active compounds. Such an approach was used in research in a similar area [8]. Furthermore, the activity of T. schischkiniialkaloids against influenza A(H1N1) virus has...

Keywords

Influenza Alkaloid Cytisine Total Alkaloid Rimantadine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

The work was sponsored by a grant of the RF President for leading scientific schools No. NSh-7014.2012.3 and RFBR Grant No. 14-03-31503-mol-a.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • I. P. Tsypysheva
    • 1
    Email author
  • E. G. Galkin
    • 1
  • I. P. Baikova
    • 1
  • N. I. Fedorov
    • 2
  • P. R. Petrova
    • 3
  • Ya. R. Orshanskaya
    • 4
  • V. A. Fedorova
    • 4
  • V. V. Zarubaev
    • 4
  1. 1.Ufa Institute of ChemistryRussian Academy of SciencesUfaRussia
  2. 2.Ufa Institute of BiologyRussian Academy of SciencesUfaRussia
  3. 3.Bashkir State UniversityUfaRussia
  4. 4.Research Institute of InfluenzaRF Ministry of HealthSt. PetersburgRussia

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