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Chemistry of Natural Compounds

, Volume 51, Issue 4, pp 675–680 | Cite as

Natural Pseudoguaianolides Prepared from Damsin

  • R. Villagomez
  • M. Quiroz
  • A. Tito
  • O. Sterner
  • G. R. AlmanzaEmail author
Article

Damsin (1) is a pseudoguaianolide sesquiterpene possessing potent biological activities, reported as a metabolite of several medicinal plants belonging to the genus Ambrosia together with related compounds. Starting from 1, which can be isolated in good amounts from Ambrosia arborescens, the five natural pseudoguaianolides ambrosin (2), isodamsin (3), 3α-hydroxydamsin (4), 3α-acetoxydamsin (5), and 11β,13-dihydrodamsin (8) were prepared by regio- and stereo-selective synthetic modifications.

Keywords

sesquiterpene lactones pseudoguaianolides semi-synthesis ambrosanolides derivatization damsin 

Notes

Acknowledgment

The authors are grateful to the Swedish International Development Agency (SIDA) for support of this study, which is part of the Project “Research on Plant Biodiversity” developed between the University of San Andres (UMSA La Paz – Bolivia) and Lund University (Sweden).

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • R. Villagomez
    • 1
    • 2
  • M. Quiroz
    • 2
  • A. Tito
    • 2
  • O. Sterner
    • 1
  • G. R. Almanza
    • 2
    Email author
  1. 1.Center for Analysis and SynthesisLund UniversityLundSweden
  2. 2.Laboratorio de Bioorganica, Instituto de Investigaciones QuimicasLa PazBolivia

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