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Two New Antifungal Polyunsaturated Fatty Acid Ethyl Esters from the Red Alga Laurencia okamurai

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Chemistry of Natural Compounds Aims and scope

Two new polyunsaturated fatty acid ethyl esters, (9Z,12Z,15Z,18Z,21Z)-ethyl tetracosa-9,12,15,18,21-pentaenoate (1) and (10Z,13Z)-ethyl nonadeca-10,13-dienoate (2), were isolated from a re-collection of the red alga Laurencia okamurai Yamada, together with three known analogues, (9Z,12Z)-ethyl nonadeca-9,12-dienoate (3), (Z)-ethyl octadec-13-enoate (4), and (Z)-ethyl hexadec-11-enoate (5). Their structures were elucidated on the basis of detailed spectroscopic analysis, including IR, HR-EI-MS, and 1D and 2D NMR. In in vitro bioassays, all the isolates were evaluated for their antifungal activity against four fungi, including Candida glabrata (537), Trichophyton rubrum (Cmccftla), Cryptococcus neoformans (32609), and Aspergillus fumigatus (07544).

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Acknowledgment

This research work was financially supported by the National Natural Science Foundation of China (Nos. 20862013, 81001397, and 21162016) and the Natural Science Foundation of Jiangxi Province, China (No. 2010GQY0217).

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Authors and Affiliations

  1. School of Pharmacy, Nanchang University, 461 Bayi Road, 330006, Nanchang, P. R. China

    Mei-Tang Feng, Xiao-Qing Yu, Peng Yang, Hui Yang, Kun Lin & Shui-Chun Mao

  2. Institute of Translational Medicine, Nanchang University, 330031, Nanchang, P. R. China

    Shui-Chun Mao

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  1. Mei-Tang Feng
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  2. Xiao-Qing Yu
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  3. Peng Yang
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  4. Hui Yang
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  5. Kun Lin
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Correspondence to Shui-Chun Mao.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2015, pp. 367–370.

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Feng, MT., Yu, XQ., Yang, P. et al. Two New Antifungal Polyunsaturated Fatty Acid Ethyl Esters from the Red Alga Laurencia okamurai . Chem Nat Compd 51, 418–422 (2015). https://doi.org/10.1007/s10600-015-1306-8

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  • DOI: https://doi.org/10.1007/s10600-015-1306-8

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