9-(N,N-Dimethyl)-4,7-megastigmedien-3-one (1) was isolated from Pachysandra terminalis and identified by 1D and 2D NMR spectroscopic and mass spectrometric methods. Compound 1 revealed significant anti-metastasis effect on cancer cell migration and invasion through suppressing the expressions of p-PKCζ and p-integrin β1 in human breast cancer cells, and also showed anti-angiogenic activity on human umbilical vein endothelial cells.
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This work was supported by grants from the National Natural Science Foundation of China (NSFC) (81072540) and the Tianjin Research Program of Applied Basic and Cutting-edge Technologies (11JCZDJC20900, 12JCZDJC25800).
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Published in Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2015, pp. 273–276.
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Jin, MN., Ma, SN., Zhai, HY. et al. A New Megastigmane Alkaloid from Pachysandra terminalis with Antitumor Metastasis Effect. Chem Nat Compd 51, 311–315 (2015). https://doi.org/10.1007/s10600-015-1267-y
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DOI: https://doi.org/10.1007/s10600-015-1267-y