From the MeOH extract of the leaves and stems of Machilus zuihoensis var. mushaensis, one new lignan, machilolin-B (1), together with 10 known compounds, zuonin B (2), (+)-9,9′-O-diferuloylsecoisolariciresinol (3), (E)-3-(3-hydroxybut-1-enyl)-2,4,4-trimethylcyclohexa-2,5-dienone (4), 5-[(1R,5R,8S)-8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo[3.2.1]oct-8-yl]-3-methyl-2,4-pentadienoic acid (5), vanillin (6), rhamnetin-3-O-β-D-galactopyranoside (7), 2-hydroxy-3,4-dioxopentanal (8), a mixture of β-sitosterol (9) and stigmasterol (10), and β-sitosteryl-β-D-glucoside (11), have been isolated. Among them, compound 3 was demonstrated to have significant cytotoxic activity against the DU145, LNCaP, and A549 cell lines. Compound 11 also possessed moderate antiproliferative activities against DU145 cell lines.
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References
J. C. Liao, Lauraceae in Flora of Taiwan, 2nd Ed.,Vol. II, 1996, p. 433.
G. Li, C. S. Lee, M. H. Woo, S. H. Lee, H. W. Chang, and J. K. Son, Biol. Pharm. Bull., 27, 1147 (2004).
J. S. Lee, J. Kim, Y. U. Yu, and Y. C. Kim, Arch. Pharm. Res., 27, 1043 (2004).
Y. U. Yu, S. Y. Kang, H. Y. Park, S. H. Sung, E. J. Lee, S. Y. Kim, and Y. C. Kim, J. Pharm. Pharmacol., 52, 1163 (2000).
M. Konaka, I. Torige, K. Suwa, and T. Kurobe, Nippon Kodo Co., Ltd., Japan, Jpn. Kokai Tokkyo Koho, JP 2005198854 A 20050728 (2005).
H. S. Yun-Choi, J. H. Kim, S. O. Kim, and J. R. Lee, Nat. Prod. Res., 17, 161 (1986).
B. Z. Ahn and J. K. Rhee, Yakhak Hoechi, 30, 253 (1986).
C. Y. Chen, M. J. Cheng, Y. J. Chiang, J. C. Bai, C. T. Chiu, R. J. Lin, Y. R. Hsui, and W. L. Lo, Nat. Prod. Res., 23, 871 (2009).
B. Y. Park, B. S. Min, and O. K. Kwong, Biol. Pharm. Bull., 27, 1305 (2004).
K. Hiroyuki, M. Yoshihiro, and S. Yutaka, Phytochemistry, 30, 315 (1991).
V. Milovanovic, N. S. Radulovic, V. D. Mitic, R. M. Palic, and G. S. Stojanovic, J. Essent. Oil Res., 20, 310 (2008).
Y. Todoroki, S. Nakano, N. Hirai, T. Mitsui, and H. Ohigashi, Biosci. Biotechnol. Biochem., 61, 1872 (1997).
E. Gaillard, F. Muyard, F. Bevalot, A. Regnier, and J. Vaquette, Ann. Pharm. Fr., 53, 75 (1995).
M. S. Marzouk, F. A. Moharram, R. A. El Dib, S. M. El-Shenawy, and A. F. Tawfike, Oenothera Speciosa. Molecules, 14, 1456 (2009).
E. O. Edney, D. J. Driscoll, W. S. Weathers, T. E. Kleindienst, T. S. Conver, C. D. McIver, and W. Li, Aerosol Sci. Technol., 35, 998 (2001).
C. Y. Chen, F. R. Chang, and Y. C. Wu, J. Chin. Chem. Soc., 44, 313 (1997).
C. K. Lee, P. H. Lee, and Y. H. Kuo, J. Chin. Chem. Soc., 48, 1053 (2001).
M. F. Jim, Y. L. Ming, and S. C. Yu, Phytochemistry, 29, 3048 (1990).
R. S. Gieni, Y. Li, and K. T. HayGlass, J. Immunol. Methods, 187, 85 (1995).
Acknowledgment
These first three authors (R.-J. Lin, M.-J. Cheng, and W.-L. Lo) contributed equally to this work and should be regarded as the first authors of this publication. This investigation was supported by a grant from the National Science Council of the Republic of China (FYU1300-98-15 and NSC 98-2320-B-242-004-MY2).
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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2014, pp. 850–853.
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Lin, RJ., Cheng, MJ., Chen, WY. et al. Phytochemical Investigation and Cytotoxic Evaluation of Components of Leaves and Stems of Machilus zuihoensis var. mushaensis . Chem Nat Compd 50, 978–981 (2014). https://doi.org/10.1007/s10600-014-1140-4
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DOI: https://doi.org/10.1007/s10600-014-1140-4