The naturally occurring octacyclopeptide brachystemin F was synthesized for the first time in the present study by a two-step solid-phase/solution strategy. All the amino acids in this study have the L-configuration. The linear octapeptide was assembled by standard Fmoc solid-phase peptide synthesis (SPPS), and subsequent cyclization was carried out by the solution method. The target compound was purified by preparative RP-HPLC, and its structure was identified by 1H NMR, 13C NMR, and MS.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2014, pp. 775–777.
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Li, Rw., Li, Wj., Wu, Mc. et al. Total Synthesis of the Octacyclopeptide Brachystemin F. Chem Nat Compd 50, 897–899 (2014). https://doi.org/10.1007/s10600-014-1109-3
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DOI: https://doi.org/10.1007/s10600-014-1109-3