We studied the alkaloid constituents and bioactivity of Sophora flavescens (Leguminosae). The constituents were isolated with silica gel column chromatography, semi-preparative HPLC, Sephadex LH-20, and MPLC packed with MCI gel, and their structures were elucidated on the basis of physical characteristics and spectral data. Compounds 1 and 5–8 were evaluated for their in vitro cytotoxicity against human tumor HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Ten alkaloids were obtained, and their structures were identified as 17β-hydroxysophoridine (1), matrine (2), sophocarpine (3), sophoridine (4), isomatrine (5), 7,11-dehydromatrine (6), mamanine (7), sophoranol (8), oxymatrine (9), and oxysophocarpine (10). Compound 1 is a new alkaloid, and compound 7 was isolated from the Sophora flavescens for the first time. None of the compounds were cytotoxic to five human cancer cell lines.
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Acknowledgment
This work was financially supported by the National Natural Science Foundation (Grant Nos. U0932602 and 90813004) and the 973 Program (Grant Nos. 2011CB915503 and 2009CB522300).
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2014, pp. 758–760.
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Lei, W., Xing-De, W., Juan, H. et al. A New Quinolizidine Alkaloid from Sophora flavescens . Chem Nat Compd 50, 876–879 (2014). https://doi.org/10.1007/s10600-014-1104-8
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DOI: https://doi.org/10.1007/s10600-014-1104-8