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Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin

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Chemistry of Natural Compounds Aims and scope

Mono-substituted spin-labeled compounds were synthesized from Mannich reactions of dihydroquercetin with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl. According to preliminary data, the compounds possessed antioxidant activity and selective cytotoxicity against various tumor cells and were promising for biomedical tests including magnetic resonance tomography.

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Acknowledgment

The work was supported financially by RFBR Grant No. 12-03-00718a and the Moscow Administration Program (Contract No. 16/12-Gen-M). Spectral characteristics of the synthesized compounds were obtained at the Chemical Service, CCU, SB, RAS.

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Authors and Affiliations

  1. N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Prosp. Akad. Lavrent̕eva, 9, Russia

    N. V. Kosheleva, E. I. Chernyak, Yu. F. Polienko, S. V. Morozov & I. A. Grigor̕ev

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  1. N. V. Kosheleva
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  2. E. I. Chernyak
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  3. Yu. F. Polienko
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  4. S. V. Morozov
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  5. I. A. Grigor̕ev
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Correspondence to N. V. Kosheleva.

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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2014, pp. 231–235.

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Kosheleva, N.V., Chernyak, E.I., Polienko, Y.F. et al. Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin. Chem Nat Compd 50, 261–265 (2014). https://doi.org/10.1007/s10600-014-0927-7

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  • DOI: https://doi.org/10.1007/s10600-014-0927-7

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