New analogs of natural (2′-5′)-oligoadenylates containing ribavirin or BAP-riboside fragments in addition to adenine 2′,3′-anhydronucleoside units were obtained. The synthesized compounds were highly stable to enzymatic hydrolysis by snake venom phosphodiesterase. It was shown that ribavirin-containing (2′-5′)-oligonucleotides could be used for elimination of pathogenic raspberry ringspot virus in culture in vitro of microrunners of black current and cherry.
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Translated from Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2013, pp. 613–618.
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Kulak, T.I., Tsibul′skaya, I.A., Tkachenko, O.V. et al. Synthesis and properties of 2′,3′-anhydro derivatives of (2′-5′)-oligoadenylates containing modified heterobases. Chem Nat Compd 49, 716–722 (2013). https://doi.org/10.1007/s10600-013-0715-9
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DOI: https://doi.org/10.1007/s10600-013-0715-9