Synthesis of tricrozarin b, a pigment of Tritonia crocosmaeflora
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Tricrozarin B (1) was isolated from bulbs of Tritonia crocosmaeflora Lemoine (Iridaceae) . It, lomazarin (2) [2, 3], and tricrozarin A  are rare examples of polymethoxynaphthazarins isolated from higher plants. Tricrozarin B exhibited cytotoxic activity in vitro against Hela-S3 cells and antitumor activity in vivo against murine sarcoma S-180  and melanoma B-16 .
The preparative production of tricrozarin B is interesting for further research of its biological activity and for use as starting material in the synthesis of other natural products and their analogs because of its poor availability.
Long before it was observed in nature, trimethoxynaphthazarin 1 was known as a derivative of spinochrome D, a pigment of the sea urchins Pseudocentrotus depressus and Echinotrix calamaris [3, 6], that was prepared by its methylation using diazomethane [6, 7].
KeywordsMeOH Dimethyl Ether Diazomethane Naphthoquinone Me2CO
The work was financed by the Russian Academy of Sciences (RAS Presidium Grant No. 12-I-P6-11 Molecular and Cellular Biology, a grant of the RAS FEB, SB, and UB No. 12-II-SU-05-006, and a grant of the FEB RAS No. 12-III-A-05-062).
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