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Search for compounds with antiviral activity among synthetic (-)-cytisine derivatives

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Chemistry of Natural Compounds Aims and scope

The antiviral activity of several amides and thio- and carboxamides of (-)-cytisine in addition to bromination and nitration products of its 2-pyridone core was studied. Compounds with a selectivity index close to 10 were found.

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Acknowledgment

The work was supported by the RFBR Grant No. 12-03-00724-a and a grant of the RF President for support of leading scientific schools NSh-7014.2012.3.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 450054, Ufa, Prosp. Oktyabrya, 71, Russia

    I. P. Tsypysheva, A. V. Koval’skaya, A. N. Lobov, I. A. Petrenko, E. A. Nikolaeva & M. S. Yunusov

  2. Research Institute of the Flu, Ministry of the Russian Federation for Health and Social Development, 197376, St. Petersburg, Ul. Prof. Popova, 15/17, Russia

    V. V. Zarubaev, L. A. Karpinskaya & A. A. Shtro

Authors
  1. I. P. Tsypysheva
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  2. A. V. Koval’skaya
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  3. A. N. Lobov
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  4. V. V. Zarubaev
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  5. L. A. Karpinskaya
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  6. I. A. Petrenko
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  7. E. A. Nikolaeva
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  8. A. A. Shtro
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  9. M. S. Yunusov
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Corresponding author

Correspondence to I. P. Tsypysheva.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2012, pp. 920–923.

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Tsypysheva, I.P., Koval’skaya, A.V., Lobov, A.N. et al. Search for compounds with antiviral activity among synthetic (-)-cytisine derivatives. Chem Nat Compd 48, 1042–1046 (2013). https://doi.org/10.1007/s10600-013-0460-0

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  • DOI: https://doi.org/10.1007/s10600-013-0460-0

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