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Synthesis and antituberculosis activity of conjugates of the diterpenoid isosteviol and the drug dimephosphon

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Chemistry of Natural Compounds Aims and scope

Conjugates of the diterpenoid isosteviol (16-oxo-ent-beyeran-19-oic acid) and the drug dimephosphon (1,1dimethyl-3-oxobutylphosphonic acid dimethyl ester) were synthesized. They inhibited completely growth of M. tuberculosis (H37Rv, in vitro) with MIC values of 5–10 μg/mL (MIC value of the antituberculosis drug isoniazid in a control was 0.5 μg/mL).

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Acknowledgment

The work was supported financially by the RAS Presidium Program No. 8 “Development of Organic Synthesis Methods and Creation of Compounds with Valuable Applied Properties”; the RAS OKhNM program No. 6 “Chemistry and Physicochemistry of Supramolecular Systems and Atomic Clusters”; and the RFBR (Grant No. 10-03-00499-a).

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Authors and Affiliations

  1. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, 420088, Kazan, Ul. Arbuzova, 8, Russia

    B. F. Garifullin, V. F. Mironov & V. E. Kataev

  2. Republic Clinical Antituberculosis Dispensary, Ministry of Health, 420061, Kazan, Ul. P. Lumumby, 20, Republic of Tatarstan, Russia

    R. V. Chestnova

Authors
  1. B. F. Garifullin
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  2. R. V. Chestnova
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  3. V. F. Mironov
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  4. V. E. Kataev
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Correspondence to V. E. Kataev.

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Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2012, pp. 710–713.

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Garifullin, B.F., Chestnova, R.V., Mironov, V.F. et al. Synthesis and antituberculosis activity of conjugates of the diterpenoid isosteviol and the drug dimephosphon. Chem Nat Compd 48, 794–798 (2012). https://doi.org/10.1007/s10600-012-0385-z

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  • DOI: https://doi.org/10.1007/s10600-012-0385-z

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