2-(N-cytisinyl)acetamide or 3-(N-cytisinyl)propanamide were prepared by treatment of the methyl esters of N-cytisinylacetic or 3-(N-cytisinyl)propanoic acids with aqueous NH4OH. N-(2-Aminoethyl)-or N-(3-aminopropyl)cytisine was synthesized by reduction of the amide with (i-Bu)2AlH.
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The work was supported financially by the RAS Presidium Basic Research Program “Development of Organic Synthesis Methodology and Creation of Compounds with Valuable Applied Properties.”
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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2012, pp. 393–396.
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Shishkin, D.V., Lobov, A.N., Baibulatova, N.Z. et al. Synthesis of N-(2-aminoethyl)- and N-(3-aminopropyl)cytisine. Chem Nat Compd 48, 436–439 (2012). https://doi.org/10.1007/s10600-012-0268-3
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DOI: https://doi.org/10.1007/s10600-012-0268-3