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A new acylated triterpene with antimicrobial activity from the leaves of Rauvolfia vomitoria

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Chemistry of Natural Compounds Aims and scope

A new acylated tritrepene, 3β-hexadecanoyloxy-lup-20(29)-en-21-ol (1), along with seven known compounds, lupeol (2), betulinic acid (3), ursonic acid (4), -sitosterol (5), β-stigmasterol (6), 3-O-β-D-glucopyranosyl-β-stigmasterol (7), and palmitic acid (8), were isolated from the leaves of Rauvolfia vomitoria (Apocynaceae). Their structures were established on the basis of spectroscopic analysis and chemical evidence. The new acylated triterpene exhibited interesting antimicrobial activity against Candida albicans (a yeast) with the MIC value 64 μg/mL.

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Acknowledgment

One of the authors (J. Wandji) is grateful for a grant (No. F/2624-3 F) from the International Foundation for Science (Sweden), and to the sponsorship of the “Universite Paris Descartes, France” during his multiple research visits in the “Laboratoire de Pharmacognosie, Faculte des Sciences Biologiques et Pharmaceutiques de Paris”.

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Authors and Affiliations

  1. Laboratory of Synthesis and Natural Products, Department of Organic Chemistry, University of Yaounde-1, Faculty of Science, P. O. Box 812, Yaounde, Cameroon

    Simone Veronique Fannang, Celine Djama Mbazoa, Joseph Itbert Momo & Jean Wandji

  2. Department of Biochemistry, University of Dschang, Faculty of Science, P. O. Box 67, Dschang, Cameroon

    Victor Kuete

  3. Laboratoire de Pharmacognosie de lˈUniversite Paris Descartes, UMR/CNRS No. 8638, Faculte des Sciences Biologiques et Pharmaceutiques, 4-Avenue de lˈObservatoire, 75006, Paris, France

    Joseph Itbert Momo, Hanh Trinh Van-Dufat & Francois Tillequin

  4. Laboratoire de Pharmacognosie, UFR de Medecine Pharmacie Rouen, 22-Bld Gambetta, 76183, Rouen Cedex 1, France

    Elisabeth Seguin & Elizabeth Chosson

Authors
  1. Simone Veronique Fannang
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  2. Victor Kuete
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  3. Celine Djama Mbazoa
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  4. Joseph Itbert Momo
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  5. Hanh Trinh Van-Dufat
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  6. Francois Tillequin
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  7. Elisabeth Seguin
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  8. Elizabeth Chosson
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  9. Jean Wandji
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Corresponding author

Correspondence to Jean Wandji.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 362–364, May–June, 2011.

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Fannang, S.V., Kuete, V., Mbazoa, C.D. et al. A new acylated triterpene with antimicrobial activity from the leaves of Rauvolfia vomitoria . Chem Nat Compd 47, 404 (2011). https://doi.org/10.1007/s10600-011-9944-y

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  • DOI: https://doi.org/10.1007/s10600-011-9944-y

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