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Crystal structures of atisine 15-acetoxyazomethine and 15-hydroxyazomethine and their biological activities

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Chemistry of Natural Compounds Aims and scope

The 15-acetoxyazomethine derivative of atisine was prepared from atisine base. Its structure was confirmed by converting it to atisine 15-hydroxyazomethine and proved by an XSA. Atisine 15-acetoxyazomethine exhibited antiarrhythmic activity in rat cardiac arrhythmia models induced by CaCl2 and aconitine. Atisine 15-acetoxyazomethine, in contrast with atisine 15-hydroxyazomethine, exhibited local anesthetic activity.

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References

  1. B. T. Salimov, Zh. Kh. Kuzibaeva, and F. N. Dzhakhangirov, Khim. Prir. Soedin., 384 (1996).

  2. D. Dvornik and O. E. Edwards, Can. J. Chem., 35, 860 (1957).

    CAS  Google Scholar 

  3. S. W. Pelletier and P. C. Parthasarathy, J. Am. Chem. Soc., 87, 777 (1965).

    Article  PubMed  CAS  Google Scholar 

  4. B. T. Salimov, Khim. Prir. Soedin., 84 (1993).

  5. S. W. Pelletier, W. H. De Camp, and N. V. Mody, J. Am. Chem. Soc., 100, 7976 (1978).

    Article  CAS  Google Scholar 

  6. S. W. Pelletier, N. V. Mody, H. K. Desai, J. Finer-Moore, J. Nowacki, and B. S. Joshi, J. Org. Chem., 48, 1787 (1983).

    Article  CAS  Google Scholar 

  7. G. M. Sheldrick, Program for Empirical Absorption Correction of Area Detector Data, University of Goettingen, Goettingen, 1996.

  8. M. R. Malinow, F. F. Batlle, and B. Malamud, Am. J. Physiol., 175, 8 (1953).

    PubMed  CAS  Google Scholar 

  9. F. N. Dzhakhangirov, M. N. Sultankhodzhaev, B. Tashkhodzhaev, and B. T. Salimov, Khim. Prir. Soedin., 257 (1997).

  10. M. L. Belen'kii, Elements of Quantitative Assessment of the Pharmacological Effect [in Russian], Medgiz, Leningrad, 1963.

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences, Republic of Uzbekistan, Tashkent

    B. T. Salimov, B. Tashkhodzhaev, M. Sh. Kodirova, F. M. Tursunkhodzhaeva & F. N. Dzhakhangirov

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  1. B. T. Salimov
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  2. B. Tashkhodzhaev
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  3. M. Sh. Kodirova
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  4. F. M. Tursunkhodzhaeva
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  5. F. N. Dzhakhangirov
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Correspondence to B. Tashkhodzhaev.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 238– 241, March–April, 2011.

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Salimov, B.T., Tashkhodzhaev, B., Kodirova, M.S. et al. Crystal structures of atisine 15-acetoxyazomethine and 15-hydroxyazomethine and their biological activities. Chem Nat Compd 47, 261–264 (2011). https://doi.org/10.1007/s10600-011-9897-1

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  • DOI: https://doi.org/10.1007/s10600-011-9897-1

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