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Influence of mechanical treatment on the properties of betulin, betulin diacetate, and their mixture with water-soluble polymers

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The influence of mechanical treatment on the properties of betulin, betulin diacetate, and their mixture with water-soluble polymers was studied. It was shown that mechanical treatment in a planetary mill-activator disordered the crystalline structure of betulin and betulin diacetate. Composites of betulin with polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG) that gave an increased betulin concentration upon dissolution in water were prepared. It was shown that H-bonds formed between betulin and PVP upon mechanical activation of their mixtures.

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Acknowledgment

The work was supported financially by the RF President Committee for Grants in Support of Leading Scientific Schools (NSh-4357.2010.3), the CRDF (RUX0-008-NO-06), the RF Ministry of Education and Science (RNP.2.2.2.2/340), and the RAS Presidium Program Fundamental Science – Medicine. We thank T. Drebushchak and N. Tumanov for recording the x-ray diffraction patterns.

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Authors and Affiliations

  1. Institute of Solid-State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences, ul. Kutateladze, 18, Novosibirsk, 630128, Russia

    M. A. Mikhailenko, T. P. Shakhtshneider & V. V. Boldyrev

  2. Scientific-Educational Center Molecular Design and Ecologically Safe Technologies of Novosibirsk State University, ul. Pirogova, 2, Novosibirsk, 630090, Russia

    M. A. Mikhailenko, T. P. Shakhtshneider, V. A. Drebushchak & V. V. Boldyrev

  3. Institute of Geology and Mineralogy, Siberian Branch, Russian Academy of Sciences, prosp. Akad. Koptyuga, 3, Novosibirsk, 630090, Russia

    V. A. Drebushchak

  4. Institute of Chemistry and Chemical Engineering, Siberian Branch, Russian Academy of Sciences, ul. K. Marksa, 42, Krasnoyarsk, 660049, Russia

    S. A. Kuznetsova & G. P. Skvortsova

Authors
  1. M. A. Mikhailenko
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  2. T. P. Shakhtshneider
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  3. V. A. Drebushchak
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  4. S. A. Kuznetsova
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  5. G. P. Skvortsova
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  6. V. V. Boldyrev
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Corresponding author

Correspondence to M. A. Mikhailenko.

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Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 211–214, March–April, 2011.

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Mikhailenko, M.A., Shakhtshneider, T.P., Drebushchak, V.A. et al. Influence of mechanical treatment on the properties of betulin, betulin diacetate, and their mixture with water-soluble polymers. Chem Nat Compd 47, 229–233 (2011). https://doi.org/10.1007/s10600-011-9889-1

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  • DOI: https://doi.org/10.1007/s10600-011-9889-1

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