The amino-acid composition of the active fraction of a protein complex was determined. An analysis of the N-terminal amino acids found threonine, glycine, serine, proline, and valine at N-terminuses. The protein complex at a dose of 100 μg/mL suppressed incorporation of 14C-thymidine marker by 64.0 ± 1.9% in a radiometric cytotoxicology test for KML murine melanoma cell proliferation. The protein complex contained protease inhibitors, inhibited the growth of tumor strain AKATON by greater than 60%, and did not inhibit bone marrow cell proliferation.
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 797–801, November–December, 2010.
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Ibragimov, F.A., Beresneva, Y.V., Kuznetsova, N.N. et al. Biological activity of the protein complex from soy meal. Chem Nat Compd 46, 935–940 (2011). https://doi.org/10.1007/s10600-011-9787-6
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DOI: https://doi.org/10.1007/s10600-011-9787-6