Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.

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Correspondence to Feng Zhu.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 674–676, September–October, 2011.

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Zhu, F., Chen, G., Chen, X. et al. Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi. Chem Nat Compd 47, 767–769 (2011). https://doi.org/10.1007/s10600-011-0053-8

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Keywords

  • aspergicin
  • mangrove epiphytic fungus
  • mixed fermentation
  • NMR assignment
  • antibacterial activity