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Chemistry of Natural Compounds

, Volume 47, Issue 5, pp 767–769 | Cite as

Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

  • Feng ZhuEmail author
  • Guangying Chen
  • Xin Chen
  • Meizhen Huang
  • Xueqin Wan
Article

A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.

Keywords

aspergicin mangrove epiphytic fungus mixed fermentation NMR assignment antibacterial activity 

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Feng Zhu
    • 1
    Email author
  • Guangying Chen
    • 2
  • Xin Chen
    • 1
  • Meizhen Huang
    • 1
  • Xueqin Wan
    • 3
  1. 1.Department of Chemistry and Chemical EngineeringFoshan UniversityFoshanP. R. China
  2. 2.Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, School of Chemistry & Chemical EngineeringHainan Normal UniversityHaikouP. R. China
  3. 3.School of Medical ScienceFoshan UniversityFoshanP. R. China

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