Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi
- 560 Downloads
A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.
Keywordsaspergicin mangrove epiphytic fungus mixed fermentation NMR assignment antibacterial activity
- 8.F. Zhu, Y. Lin, J. Ding, X. Wang, and L. Huang, Chem. Ind. Forest Prod., 27 (1), 8 (2007).Google Scholar
- 9.F. Zhu, G. Hu, X. Chen, Y. Yuan, M. Huang, H. Sun, W. Xiang, and Y. Lin, Acta Scientiarum Naturalium Universitatis Sunyatseni, 48 (6), 79 (2009).Google Scholar
- 11.F. Zhu, X. H. Liu, L. Wen, Y. C. Lin, S. N. Zhou, and L. L. P. Vrijmoed, Acta Scientiarum Naturalium Universitatis Sunyatseni, 44 (4), 66 (2005).Google Scholar