Chemistry of Natural Compounds

, Volume 47, Issue 5, pp 767–769 | Cite as

Aspergicin, a new antibacterial alkaloid produced by mixed fermentation of two marine-derived mangrove epiphytic fungi

  • Feng ZhuEmail author
  • Guangying Chen
  • Xin Chen
  • Meizhen Huang
  • Xueqin Wan

A new alkaloid designated as aspergicin (1), together with a previous secondary metabolite, neoaspergillic acid (2), and a common compound, ergosterol (3), were isolated from the mixed cultured mycelia of two marine-derived mangrove epiphytic Aspergillus sp. fungi. Extensive application of 1D and 2D NMR techniques was made to characterize the structure and to establish the 1H and 13 C assignments of compound 1. In the antibacterial assays, both compounds 1 and 2 showed significant antibacterial activity against some selected Gram bacteria.


aspergicin mangrove epiphytic fungus mixed fermentation NMR assignment antibacterial activity 


  1. 1.
    M. Cueto, P. R. Jensen, C. Kauffman, W. Fenical, E. Lobkovsky, and J. Clardy, J. Nat. Prod., 64, 1444 (2001).PubMedCrossRefGoogle Scholar
  2. 2.
    D. C. Oh, P. R. Jensen, C. A. Kauffman, and W. Fenical, Bioorg. Med. Chem., 13, 5267 (2005).PubMedCrossRefGoogle Scholar
  3. 3.
    F. Zhu and Y. Lin, Chin. Sci. Bull., 51, 1426 (2006).CrossRefGoogle Scholar
  4. 4.
    D. C. Oh, P. R. Jensen, C. A. Kauffman, and W. Fenical, J. Nat. Prod., 70, 515 (2007).PubMedCrossRefGoogle Scholar
  5. 5.
    R. K. Pettit, Appl. Microbiol. Biotechnol., 83, 19 (2009).PubMedCrossRefGoogle Scholar
  6. 6.
    C. Li, W. Ding, Z. She, and Y. Lin, Chem. Nat. Comp., 44, 163 (2008).CrossRefGoogle Scholar
  7. 7.
    N. Tan, Y. Tao, J. Pan, S. Wang, F. Xu, Z. She, Y. Lin, and E. B. G. Jones, Chem. Nat. Comp., 44, 296 (2008).CrossRefGoogle Scholar
  8. 8.
    F. Zhu, Y. Lin, J. Ding, X. Wang, and L. Huang, Chem. Ind. Forest Prod., 27 (1), 8 (2007).Google Scholar
  9. 9.
    F. Zhu, G. Hu, X. Chen, Y. Yuan, M. Huang, H. Sun, W. Xiang, and Y. Lin, Acta Scientiarum Naturalium Universitatis Sunyatseni, 48 (6), 79 (2009).Google Scholar
  10. 10.
    M. Masaki, Y. Chigira, and M. Ohta, J. Org. Chem., 31 (12), 4143 (1966).CrossRefGoogle Scholar
  11. 11.
    F. Zhu, X. H. Liu, L. Wen, Y. C. Lin, S. N. Zhou, and L. L. P. Vrijmoed, Acta Scientiarum Naturalium Universitatis Sunyatseni, 44 (4), 66 (2005).Google Scholar
  12. 12.
    D. A. Dias and S. Urban, Nat. Prod. Commun., 4 (4), 489 (2009).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Feng Zhu
    • 1
    Email author
  • Guangying Chen
    • 2
  • Xin Chen
    • 1
  • Meizhen Huang
    • 1
  • Xueqin Wan
    • 3
  1. 1.Department of Chemistry and Chemical EngineeringFoshan UniversityFoshanP. R. China
  2. 2.Hainan Provincial Key Laboratory of Tropical Pharmaceutical Herb Chemistry, School of Chemistry & Chemical EngineeringHainan Normal UniversityHaikouP. R. China
  3. 3.School of Medical ScienceFoshan UniversityFoshanP. R. China

Personalised recommendations