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New cleistanthane diterpenoids and 3,4-seco-cleistanthane diterpenoids from Croton oblongifolius

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Chemistry of Natural Compounds Aims and scope

Two new cleistanthane-type diterpenoids, 3-hydroxycleistantha-13(17),15-diene (1) and 3,4-seco-cleistantha4(18),13(17),15-trien-3-oic acid (2), were isolated from the stem bark of Croton oblongifolius Roxb. Epoxidation of 2 gave two epoxides 3 and 4. Their structures were established on the basis of spectroscopic data. Compound 1 showed nonspecific strong cytotoxicity against human tumor cell lines, compound 2 showed weak activity, and compounds 3 and 4 were inactive.

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Acknowledgment

We thank the Thailand Research Fund (DBG4880013), the Thai Government (Nan), and the Graduate School and Department of Chemistry, Faculty of Science, Chulalongkorn University for financial support.

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Authors and Affiliations

  1. Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwon, Bangkok, 10330, Thailand

    S. Roengsumran, P. Pata, N. Ruengraweewat, J. Tummatorn, S. Pornpakakul, P. Sangvanich & A. Petsom

  2. Institute of Biotechnology and Genetic Engineering, Chulalongkorn University, Phayathai Road, Pathumwon, Bangkok, 10330, Thailand

    S. Puthong & A. Petsom

Authors
  1. S. Roengsumran
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  2. P. Pata
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  3. N. Ruengraweewat
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  4. J. Tummatorn
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  5. S. Pornpakakul
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  6. P. Sangvanich
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  7. S. Puthong
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  8. A. Petsom
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Corresponding author

Correspondence to A. Petsom.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, pp. 540–543, September–October, 2009.

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Roengsumran, S., Pata, P., Ruengraweewat, N. et al. New cleistanthane diterpenoids and 3,4-seco-cleistanthane diterpenoids from Croton oblongifolius . Chem Nat Compd 45, 641–646 (2009). https://doi.org/10.1007/s10600-009-9442-7

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  • DOI: https://doi.org/10.1007/s10600-009-9442-7

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