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Synthesis of phenacyl derivatives of frangula-emodin and their HIV-1 RNase H activity

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Chemistry of Natural Compounds Aims and scope

New functionally substituted phenacyl derivatives of frangula-emodin were synthesized and tested as inhibitors of HIV-1 RNase H activity.

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Acknowledgment

We thank Prof. E. Tramontano for help in testing samples for HIV-1 RNase H activity. The work was supported financially by Grant EC-INTAS 04-82-7146.

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Authors and Affiliations

  1. A. B. Bekturov Institute of Chemical Sciences, Almaty, Kazakhstan

    T. V. Kharlamova

  2. Department of Biomedical Science and Technology, University of Cagliari, Monserrato, Italy

    T. V. Kharlamova

Authors
  1. T. V. Kharlamova
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Correspondence to T. V. Kharlamova.

Additional information

Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 425–427, July–August, 2009.

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Kharlamova, T.V. Synthesis of phenacyl derivatives of frangula-emodin and their HIV-1 RNase H activity. Chem Nat Compd 45, 500–502 (2009). https://doi.org/10.1007/s10600-009-9398-7

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  • DOI: https://doi.org/10.1007/s10600-009-9398-7

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