Two new phenolic compounds, 4-O-β-D-(6-O-gentisoylglucopyranosyl) vanillic acid (1), 2-O-β-D-(6-O-gentisoylglucopyranosyl) gentisic acid (2), together with three known compounds, vanillic acid (3), syringic acid (4), and gentisic acid (5), were isolated from the whole part of Stenoloma chusanum (L.) Ching. Structures of the two new compounds 1, 2 were elucidated on the basis of spectroscopic methods, including twodimensional NMR techniques and HR ESI-MS analysis. The compounds′ activities against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Epidermophyton floccosum, and Aspergillus niger were determined, and the minimal inhibitory concentrations (MIC) were 25–100 μg/mL.
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Acknowledgment
The authors would like to thank Professor Yong-nian Shen in the Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College for assistance in antifungal susceptibility testing.
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Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 161–164, March–April, 2009.
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Ren, B., Xia, B., Li, W. et al. Two novel phenolic compounds from Stenoloma chusanum and their antifungal activity. Chem Nat Compd 45, 182–186 (2009). https://doi.org/10.1007/s10600-009-9298-x
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DOI: https://doi.org/10.1007/s10600-009-9298-x