The effect of natural and synthetic polyhydroxy-1,4-naphthoquinones on the hydrolytic activity of α-galactosidase from marine bacteria was studied. It was shown that the inhibiting properties relative to the enzyme depended on the nature of the substituents, their number, and their position in the structure of these compounds.
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Acknowledgment
We thank Head Scientist of the Laboratory of Marine Microbiology, Doctor of Chemical Sciences O. I. Nedashkovskaya for supplying the bacterial biomass.
The work was performed under the auspies of State Contract No. 02.522.11.2013 and with support of a grant of the FEB RAS 09-III-A-05-143 and the RAS Program Molecular and Cellular Biology.
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 59–63, January–February, 2009.
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Bakunina, I.Y., Kol′tsova, E.A., Pokhilo, N.D. et al. Effect of 5-hydroxy- and 5,8-dihydroxy-1,4-naphthoquinones on the hydrolytic activity of α-galactosidase. Chem Nat Compd 45, 69–73 (2009). https://doi.org/10.1007/s10600-009-9252-y
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DOI: https://doi.org/10.1007/s10600-009-9252-y