A method for chemico-enzymatic synthesis of (2′-5′)-oligonucleotides with 6-N-benzylaminopurineriboside as the nucleoside units was proposed. The method consisted of enzymatic hydrolysis of the oligonucleotides with mixed (2′-5′)-(3′-5′)-phosphodiesterbonds that were prepared by polymerization of 6-N-benzyladenosine-2′(3′)-monophosphate by using (3′-5′)-specific nuclease and phosphatase contained in the filtrate of culture medium of the mycelial fungus Spicaria violacea.
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 64–68, January–February, 2009.
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Kulak, T.I., Tkachenko, O.V., Grishan, O.Y. et al. Preparation of (2′-5′)-oligonucleotides based on 6-N-benzylaminopurineriboside using the Spicaria violacea fungal enzyme complex. Chem Nat Compd 45, 74–78 (2009). https://doi.org/10.1007/s10600-009-9249-6
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DOI: https://doi.org/10.1007/s10600-009-9249-6