Chemistry of Natural Compounds

, Volume 44, Issue 6, pp 696–700 | Cite as

Anticoccidial constituents from the stem bark of Turraeanthus africanus

  • J. C. VardamidesEmail author
  • H. El Alaoui
  • D. L. Massoma
  • A. G. B. Azebaze
  • B. Ndemangou
  • V. T. Sielinou
  • M. MeyerEmail author
  • C. P. Vivares
  • Z. T. Fomum
  • A. E. Nkengfack

In order to study some biological active products, phytochemical investigation of the stem bark of Turraeanthus africanus have led to the isolation of a novel compound 1, a new benzoic acid derivative, named turraeanthin C, and two known compounds sesamin (2) and stigmasterol. The structures of these compounds were established by spectral analysis, including two-dimensional nuclear magnetic resonance. The extract and the isolated compounds 1 and 2 showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals.

Key words

anticoccidial activity Turraeanthus africanus benzoic acid derivative Meliaceae 



This investigation was supported by grant No. 121.104401.133 from the Deustcher Akademischer Austauschdienst (DAAD) Alumni Program, Germany. We are also grateful to A. Blond and A. Deville for recording the NMR spectra, and to L. Dubost for recording the mass spectra. Many thanks to JF Dubremetz (Montpellier) for providing the β-galactosidase strain of T. gondii and the protocol for the β-galactosidase assay.


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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • J. C. Vardamides
    • 1
    Email author
  • H. El Alaoui
    • 2
  • D. L. Massoma
    • 3
  • A. G. B. Azebaze
    • 1
  • B. Ndemangou
    • 4
  • V. T. Sielinou
    • 4
  • M. Meyer
    • 5
    Email author
  • C. P. Vivares
    • 2
  • Z. T. Fomum
    • 4
  • A. E. Nkengfack
    • 4
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of DoualaDoualaCameroon
  2. 2.Universite Blaise Pascal, UMR CNRS 6023 - Laboratoire de Biologie des Protistes Parasitologie moleculaire et cellulaireCedexFrance
  3. 3.Department of Biology of Animal Organisms, Faculty of ScienceUniversity of DoualaDoualaCameroon
  4. 4.Department of Organic Chemistry, Faculty of ScienceUniversity of Yaounde IYaounde ICameroon
  5. 5.Laboratoire de Chimie des Substances Naturelles, USM 502 MNHN-UMR 5154 CNRSParisFrance

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