Anticoccidial constituents from the stem bark of Turraeanthus africanus
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In order to study some biological active products, phytochemical investigation of the stem bark of Turraeanthus africanus have led to the isolation of a novel compound 1, a new benzoic acid derivative, named turraeanthin C, and two known compounds sesamin (2) and stigmasterol. The structures of these compounds were established by spectral analysis, including two-dimensional nuclear magnetic resonance. The extract and the isolated compounds 1 and 2 showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals.
Key wordsanticoccidial activity Turraeanthus africanus benzoic acid derivative Meliaceae
This investigation was supported by grant No. 121.104401.133 from the Deustcher Akademischer Austauschdienst (DAAD) Alumni Program, Germany. We are also grateful to A. Blond and A. Deville for recording the NMR spectra, and to L. Dubost for recording the mass spectra. Many thanks to JF Dubremetz (Montpellier) for providing the β-galactosidase strain of T. gondii and the protocol for the β-galactosidase assay.
- 1.K. A. Joiner and J. F. Dubremetz, Infect. Immunol., 61, 1169 (1993).Google Scholar
- 3.N. Ekwalla and E. Tongo, Nos Plantes qui soignent, Douala, 2003, pp 34–78.Google Scholar
- 12.J. L. Jones, D. L. Hanson, M. S. Dworkin, D. L. Alderton, P. L. Fleming, J. E. Kaplan, and J. Ward, Morb. Mortal. Wkly. Rep., 49, 1 (1999).Google Scholar
- 14.L. R. Mc Dougald, Poult. Sci., 77, 1156 (1998).Google Scholar
- 16.European Commission Regulations (EC) No. 97/6 of 30 January 1997 amending Council Directive 70/524/EC concerning additives in feedingstuffs, OJ L 96, 28/3/1998, p. 39.Google Scholar