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Chemistry of Natural Compounds

, Volume 44, Issue 6, pp 696–700 | Cite as

Anticoccidial constituents from the stem bark of Turraeanthus africanus

  • J. C. VardamidesEmail author
  • H. El Alaoui
  • D. L. Massoma
  • A. G. B. Azebaze
  • B. Ndemangou
  • V. T. Sielinou
  • M. MeyerEmail author
  • C. P. Vivares
  • Z. T. Fomum
  • A. E. Nkengfack
Article

In order to study some biological active products, phytochemical investigation of the stem bark of Turraeanthus africanus have led to the isolation of a novel compound 1, a new benzoic acid derivative, named turraeanthin C, and two known compounds sesamin (2) and stigmasterol. The structures of these compounds were established by spectral analysis, including two-dimensional nuclear magnetic resonance. The extract and the isolated compounds 1 and 2 showed noteworthy activity against Toxoplasma gondii intracellular parasite in mammals.

Key words

anticoccidial activity Turraeanthus africanus benzoic acid derivative Meliaceae 

Notes

Acknowledgment

This investigation was supported by grant No. 121.104401.133 from the Deustcher Akademischer Austauschdienst (DAAD) Alumni Program, Germany. We are also grateful to A. Blond and A. Deville for recording the NMR spectra, and to L. Dubost for recording the mass spectra. Many thanks to JF Dubremetz (Montpellier) for providing the β-galactosidase strain of T. gondii and the protocol for the β-galactosidase assay.

References

  1. 1.
    K. A. Joiner and J. F. Dubremetz, Infect. Immunol., 61, 1169 (1993).Google Scholar
  2. 2.
    B. J. Luft and J. S. Remington, Clin. Infect. Dis., 15, 211 (1992).PubMedGoogle Scholar
  3. 3.
    N. Ekwalla and E. Tongo, Nos Plantes qui soignent, Douala, 2003, pp 34–78.Google Scholar
  4. 4.
    P. Tane, T. M. Akam, A. Tsopmo, P. C. Ndi, and O. Sterner, Phytochemistry, 65, 3083 (2004).PubMedCrossRefGoogle Scholar
  5. 5.
    J. C. Vardamides, A. B. Dongmo, M. Meyer, J. C. Ndom, A. G. B. Azebaze, M. R. S. Zounda, V. T. Sielinou, B. Ndemangou, A. E. Nkengfack, T. M. Ngando, and Z. T. Fomum, Chem. Pharm. Bull., 57, 1034 (2006).CrossRefGoogle Scholar
  6. 6.
    S. J. Tatsimo, P. Tane, P. V. Srinivas, B. L. Sondengam, J. Melissa, C. O. Okunji, B. M. Schuster, M. M. Iwu, and I. A. Khan, Planta Med., 71, 1145 (2005).PubMedCrossRefGoogle Scholar
  7. 7.
    A. G. Soman, J. B. Gloer, B. Koster, and D. Malloch, J. Nat.Prod., 62, 659 (1999).PubMedCrossRefGoogle Scholar
  8. 8.
    J. Dai, L. B. S. Kardono, S. Tsauri, K. Padmawinata, J. M. Pezzuto, and A. D. Kinghorn, Phytochemistry, 30, 3749 (1991).CrossRefGoogle Scholar
  9. 9.
    A. K. Barua, M. Chakrabarty, P. K. Datta, and S. Ray, Phytochemistry, 27, 3259 (1988).CrossRefGoogle Scholar
  10. 10.
    S. B. Blunt, T. B. Chen, and D. F. Wiemer, J. Nat.Prod., 61, 1400 (1998).PubMedCrossRefGoogle Scholar
  11. 11.
    S. P. Fricker and R. G. Buckley, Anticancer Res., 16, 3755 (1996).PubMedGoogle Scholar
  12. 12.
    J. L. Jones, D. L. Hanson, M. S. Dworkin, D. L. Alderton, P. L. Fleming, J. E. Kaplan, and J. Ward, Morb. Mortal. Wkly. Rep., 49, 1 (1999).Google Scholar
  13. 13.
    A. Kovacs and H. N. Masur, New Engl. J. Med., 342, 1416 (2000).PubMedCrossRefGoogle Scholar
  14. 14.
    L. R. Mc Dougald, Poult. Sci., 77, 1156 (1998).Google Scholar
  15. 15.
    H. D. Chapman, Res. Vet. Sci., 41, 281 (1986).PubMedGoogle Scholar
  16. 16.
    European Commission Regulations (EC) No. 97/6 of 30 January 1997 amending Council Directive 70/524/EC concerning additives in feedingstuffs, OJ L 96, 28/3/1998, p. 39.Google Scholar
  17. 17.
    C. Alex, J. K. Massuo, B. D. Laurence, and L. Normang, Phytochemistry, 47, 583 (1998).CrossRefGoogle Scholar
  18. 18.
    M. J. Lagarda, G. Garcia-Llatas, and R. Farre, J. Pharm. Biomed. Anal., 41, 1486 (2006).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • J. C. Vardamides
    • 1
    Email author
  • H. El Alaoui
    • 2
  • D. L. Massoma
    • 3
  • A. G. B. Azebaze
    • 1
  • B. Ndemangou
    • 4
  • V. T. Sielinou
    • 4
  • M. Meyer
    • 5
    Email author
  • C. P. Vivares
    • 2
  • Z. T. Fomum
    • 4
  • A. E. Nkengfack
    • 4
  1. 1.Department of Chemistry, Faculty of ScienceUniversity of DoualaDoualaCameroon
  2. 2.Universite Blaise Pascal, UMR CNRS 6023 - Laboratoire de Biologie des Protistes Parasitologie moleculaire et cellulaireCedexFrance
  3. 3.Department of Biology of Animal Organisms, Faculty of ScienceUniversity of DoualaDoualaCameroon
  4. 4.Department of Organic Chemistry, Faculty of ScienceUniversity of Yaounde IYaounde ICameroon
  5. 5.Laboratoire de Chimie des Substances Naturelles, USM 502 MNHN-UMR 5154 CNRSParisFrance

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