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Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors

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Abstract

Protein tyrosine phosphatase 1B (PTP1B) has received much attention due to its pivotal role in type 2 diabetes and obesity as a negative regulator of the insulin signaling pathway. Mangiferin, a xanthone glucoside, has been reported to possess significant antidiabetic activity. In the present study, a series of mangiferin derivatives was synthesized and evaluated for their PTP1B inhibitory activity. Some of the screened compounds displayed good PTP1B inhibitory activity.

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References

  1. Z. Pei, G. Liu, and T. H. Lubben, B. G. Szczepankiewicz, Curr. Pharm. Des., 10, 3481 (2004).

    Article  PubMed  CAS  Google Scholar 

  2. S. Dadke and J. Chernoff, Curr. Drug. Targets. Immune. Endocr. Metab. Disord., 3, 299 (2003).

    Article  CAS  Google Scholar 

  3. Hwa-Ok Kim and Mark A. Blaskovich, Expert Opin. Ther. Patents, 12, 871 (2002).

  4. M. Elchebly, P. Payette, E. Michaliszyn, W. Cromlish, S. Collins, A. L. Loy, D. Normandin, A. Cheng, J. Himms-Hagen, C. C. Chan, C. Ramachandran, M. J. Gresser, M. L. Tremblay, and B. P. Kennedy, Science, 283, 1544 (1999).

    Article  PubMed  CAS  Google Scholar 

  5. L. D. Klaman, O. Boss, O. D. Peroni, J. K. Kim, J. L. Martino, J. M. Zabolotny, N. Moghal, M. Lubkin, Y. B. Kim, A. H. Sharpe, A. Stricker-Krongrad, G. I. Shulman, B. G. Neel, and B. B. Kahn, Mol. Cell. Biol., 20, 5479 (2000).

    Article  PubMed  CAS  Google Scholar 

  6. T. Miura, H. Ichiki, N. Iwamoto, M. Kato, M. Kubo, H. Sasaki, M. Okada, T. Ishida, Y. Seino, and K. Tanigawa, Biol. Pharm. Bull., 24, 1009 (2001).

    Article  PubMed  CAS  Google Scholar 

  7. T. Miura, H. Ichiki, I. Hashimoto, N. Iwamoto, M. Kato, M. Kubo, E. Ishihara, Y. Komatsu, M. Okada, T. Ishida, and K. Tanigawa, Phytomedicine, 8, 85 (2001).

    Article  PubMed  CAS  Google Scholar 

  8. B. J. Goldstein, A. Bittner-Kowalezyk, M. F. White, and M. Harbeck, J. Biol. Chem., 275, 4283 (2000).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 200433, People’s Republic of China

    Hong-gang Hu, Ming-juan Wang, Qing-jie Zhao, Hong-li Liao, Ling-zhi Cai, Yan Song, Jun Zhang, Shi-chong Yu & Qiu-ye Wu

  2. Department of Pharmacy, Chang Zheng Hospital, Second Military Medical University, People’s Republic of China

    Wan-sheng Chen

Authors
  1. Hong-gang Hu
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  2. Ming-juan Wang
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  3. Qing-jie Zhao
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  4. Hong-li Liao
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  5. Ling-zhi Cai
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  6. Yan Song
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  7. Jun Zhang
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  8. Shi-chong Yu
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  9. Wan-sheng Chen
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  10. Chao-mei Liu
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  11. Qiu-ye Wu
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Corresponding author

Correspondence to Qiu-ye Wu.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 549–551, November–December, 2007.

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Hu, Hg., Wang, Mj., Zhao, Qj. et al. Synthesis of mangiferin derivatives as protein tyrosine phosphatase 1B inhibitors. Chem Nat Compd 43, 663–666 (2007). https://doi.org/10.1007/s10600-007-0223-x

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  • DOI: https://doi.org/10.1007/s10600-007-0223-x

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