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Chemical structure and biological activity of steroidal saponins from Furcraea gigantea

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Abstract

A new bisdesmosidic furostanol saponin, along with a known spirostanol saponin, furcreastatin, were isolated from Furcraea gigantea Vent. (Agavaceae). The structure of the new saponin was elucidated as 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1å 3)-O-[O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-(3β, 5α, 25R)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurost-12-one. The structural identification was performed using a combination of spectroscopic techniques and chemical conversions. Furcreastatin showed a powerful haemolytic effect in the in vitro assay, but the new bisdesmosidic furostanol saponin demonstrated only a significant inhibition of the capillary permeability activity.

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Authors and Affiliations

  1. Laboratorio de Quimica de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, PO Box 68045, CEP 21944-970, Rio de Janeiro, Brasil

    Bernadete Pereira da Silva, Patricia Oliveira Campos & Jose Paz Parente

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  1. Bernadete Pereira da Silva
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  2. Patricia Oliveira Campos
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  3. Jose Paz Parente
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Published in Khimiya Prirodnykh Soedinenii, No. 3, pp. 259–262, May–June, 2006.

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Pereira da Silva, B., Oliveira Campos, P. & Paz Parente, J. Chemical structure and biological activity of steroidal saponins from Furcraea gigantea . Chem Nat Compd 42, 316–321 (2006). https://doi.org/10.1007/s10600-006-0109-3

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  • DOI: https://doi.org/10.1007/s10600-006-0109-3

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