Chemistry of Natural Compounds

, Volume 42, Issue 2, pp 189–193 | Cite as

Cardiac glycosides from Strophanthus kombe

  • I. F. Makarevich
  • S. V. Kovalev


Twelve cardiac glycosides and aglycons were isolated from Strophanthus kombe seeds. Of these, eight were identified as cymarin, K-strophanthin-β, K-strophanthoside, periplocymarin, 17α-strophadogenin, erysimin (= helveticoside), erysimoside, and neoglucoerysimoside. Four glycosides, preliminarily designated Sk-x, Sk-y, Sk-z, and Sk-20, were new. Their chemical structures were established as 3β-O-β-D-glucopyranosyl-5β,14β,16β-trihydroxy-19-oxo-17α-card-20(22)enolide (17α-strophadogenin-3-O-β-D-glucoside), 3β-O-β-D-cymaropyranosyl-5β,14β,16β-trihydroxy-19-oxo-17α-card-20(22)enolide (17α-strophadogenin-3-O-β-D-cymaroside), 3β-O-β-D-cymaropyranosyl-4′-O-β-D-glucopyranosyl-6″-O-β-D-glucopyranosyl-5β, 14β,16β-trihydroxy-19-oxo-17α-card-20(22)enolide (17α-strophadogenin-3-O-strophanthotrioside), and 3-O-β-D-digitoxopyranosyl-4′-O-β-D-glucopyranosyl-6″-O-β-D-glucopyranosyl-5β,14β, 19-trihydroxy-card-20(22)enolide (strophanthidol-3-O-gentiobiosyldigitoxoside), respectively.

Key words

cardenolides cardenolide glycosides Strophanthus kombe separation new cardenolide glycosides 17α-strophadogenin-3-O-β-D-glucoside 17α-strophadogenin-3-O-β-D-cymaroside 17α-strophadogenin-3-O-strophanthotrioside strophanthidol-3-O-gentiobiosyldigitoxoside 


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • I. F. Makarevich
    • 1
  • S. V. Kovalev
    • 1
  1. 1.National Pharmaceutical UniversityKhar’kovUkraine

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