Abstract
The alkaloid accumulation dymanics in Veratrum lobelianum were investigated. Jervine was found from 0.02 to 0.11% in the subterranean part at all vegetation stages. The jervine content was greatest in subterranean plant organs, reaching a maximum (0.3%) during natural dying off of aerial organs. Jervine, a natural analog of serotonin, can be used as a specific fibroblast growth factor.
Similar content being viewed by others
References
N. L. Machaidze and I. S. Sikharulidze, Khim. Prir. Soedin., 659 (1982).
T. N. Kiparenko and D. M. Tsakadze, Tr. Tbilis. Gos. Univ., 192, 27 (1977).
T. Sh. Suladze and V. Yu. Vachnadze, Khim. Prir. Soedin., 335 (2001).
T. Sh. Suladze and V. Yu. Vachnadze, Khim. Prir. Soedin., 383 (2002).
B. G. Katzung and D. J. Julius, “Serotonin and the ergot alkaloids,” in: Basic and Clinical Pharmacology, B. G. Katzung, ed., Lange Medical Books, 8th Ed., New York (2001), pp. 265–291.
R. J. Boucek and T. R. Alvarez, “5-Hydroxytryptamine: a cytospecific growth stimulator of cultured fibroblasts,” Science, 167, No. 3919, 898 (1970).
T. Sh. Suladze, V. Yu. Vachnadze, and V. S. Bostaganashvili, Izv. Akad. Nauk Gruz. SSR, Ser. Khim., 27, No. 3–4, 384 (2001).
V. Yu. Vachnadze, Izv. Akad. Nauk Gruz. SSR, Ser. Khim., 1, No. 1, 28 (1975).
I. M. Hais and K. Macek, Eds., Handbuch der Papierchromatographie, Vol. I. Grundlagen und Technik, G. Fischer, Jena (1958).
T. Sh. Sharshunova, V. Shvartz, and C. Mikhalets, Thin-Layer Chromatography in Pharmacy and Clinical Biochemistry, Vol. 1 [Russian translation], Mir, Moscow (1980).
F. L. Zakirova and M. Kh. Malikova, Khim. Prir. Soedin., 226 (2001).
E. Shellard, ed., Quantitative Paper and Thin-Layer Chromatography, Academic, New York (1968).
L. F. Fieser and M. Fieser, Steroids, Reinhold Publ. Corp., New York (1959).
M. D. Gedevanishvili, L. E. Tsutsunava, and N. G. Malazoniya, Tsitologiya, 20, No. 6, 686 (1978).
Author information
Authors and Affiliations
Additional information
__________
Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 57–59, January–February, 2006.
Rights and permissions
About this article
Cite this article
Suladze, T.S., Vachnadze, V.Y., Tsakadze, D.M. et al. Alkaloid accumulation dynamics in Veratrum lobelianum growing in Georgia and biological activity of Jervine. Chem Nat Compd 42, 71–74 (2006). https://doi.org/10.1007/s10600-006-0038-1
Received:
Issue Date:
DOI: https://doi.org/10.1007/s10600-006-0038-1